Sorry, but I have problems with this article for a number of reasons including... so many things.
DNA (and RNA) does not copy perfectly. That is a foundation of biology. Minor issue, but to a biologist it seems careless.
The question of if we exist in a simulation is interesting, but like some other things, I don't think the answer should effect how we live. Life goes on and so do the moral choices we have to make. They should not be effected.
This whole discussion is considered much much better in David Brin's story "Stones of Significance". It's free at https://fennetic.net/pub/david_brin_-_stones_of_significance.pdf.
Now what everyone seems to skip, including to some degree David Brin even skips it, is the moral implications of why the simulation would be made. Maybe it is what Brin suggests or maybe it is not. He is correct that the moral implications for the creator of the simulation are very large, but what if the motivation is not what he said? Most people talking about the simulations (look way back at Simulacron 3) is about them being for marketing or psychological research.
A problem humanity faces is that we are adapted to the old tribal world. We live in such a rare, incredible time between those two worlds (ecologies). How are we, with our tribal nature, going to adapt to a world 100,000 years in the future if we are having trouble just adapting to the challenges and civilizations of today? How about if we could put people, as children, in a simulation to act as a school with lots of options to choose from, good and bad. A place where they could safely learn about what it takes to live. Well, you can easily interpret stories of heaven and earth that way. All societies have rites of passage. Fail in this simulation to learn the critical moral lessons needed in the future of humanity that where the simulation was made and you are not going to make it out of the simulation alive. It sounds a lot like some of the stories of after lifes. More interestingly it offers the moral reason for making the simulation in the first place and if we are not in a simulation, it may be needed by humanity in the future.
